World Health Organization has estimated that there are an increase number of cases deaths from cancer in the near future. Cancer has become one of the most discussed. In this study, we focus on the quality of life of the cancer patients, by using music therapy and to observe the difference between pre-test and post-test results with music treatment. This study was to examine the alternative therapies using of music to enhance, and quality of life, using the Thai Hospice Quality of Life Index (T-HQOLI), in cancer patients. The 11 cancer patients were divided into two different groups; the control (non-music) group followed their routine schedules; the music group received additional music therapy with a music leader. The results from both questionnaires, collected during 4th, 8th and 12th week, showed that music group is most significantly improved compared to the control (non-music) group. This suggested that the combination of music has the most potential to increase the quality of life for the cancer patients. It can conclude that the music treatment is a good model to improve both psychological and physiological conditions. The treatment can also be used in general clinics or hospitals as an alternative treatment for cancer patients.