Objective: Total knee replacement (TKR) is reportedly a safe and effective approach to treating osteoarthritis of the knee. However, there is no published data from Thailand about benefit in terms of long-term quality of life (QoL). Our aims were to assess long-term QoL after TKR and identify its associated factors.

Methods: This was a prospective, cross-sectional, analytical study of patients who had undergone TKR between 2008 and 2013. Questionnaires were sent to 560 randomly selected patients. Relevant clinical variables, surgi­cal and anesthetic data, and duration of hospital and ICU stays were extracted from hospital records. QoL was evaluated using the Thai version of the WHOQOL-BREF questionnaire. Scores range from 0 to 100, with 100 indicating the best state. The primary outcome was long-term QoL after TKR and secondary outcomes were fac­tors associated with QoL.

Results: The mean score within each domain was used to calculate the overall score (mean 64.6, SD 10.2), which indicated medium QoL. Educational level and length of hospital stay were the only factors significantly associ­ated with QoL (p<0.05).

Conclusion: Long-term QoL after TKR at Siriraj Hospital was assessed as medium. Educational level and length of hospital stay were the only factors associated with long-term QoL.