Second Trimester Pregnancy Termination: A Comparison of 600 and 800 Micrograms of Intravaginal Misoprostol
บุญศรี จันทร์รัชชกูล, ปิยภรณ์ ปัญญาวชิร, ยงยุทธ เหราบัตย์*
Department of Obstetrics and Gynaecology, Ramathibodi Hospital, Mahidol University, Rama VI Road, Bangkok 10400, Thailand
บทคัดย่อ
Objective: To compare the effectiveness of 600 and 800 μg of misoprostol administered intravaginally every 12 hours for termination of second trimester pregnancies.Methods: One hundred and forty-three pregnant women at 14–26 weeks' gestation were randomized in 2 groups to receive either 600 μg (N = 67), or 800 μg (N = 76) of intravaginal misoprostol every 12 hours until abortion was induced.Results: The incidences of abortion within 24 hours after initial drug administration were 82.1% (n = 55) and 78.9% (n = 60), within 48 hours 92.5% (n = 62) and 92.1% (n = 70), the mean abortion intervals were 15.2 (10.5, 20.8) hours and 15.3 (10.2, 21.8) hours, the complete abortion rates 77.6% (n = 52) and 72.4% (n = 55), and body temperature of more than 38°C were 26.9% (n = 18) and 71.1% (n = 54, p = < 0.001) in the 600 and 800 μg group, respectively. All other side-effects were similar between the 2 groups.Conclusion: In consideration of effectiveness and febrile complication, we suggest that 600 μg applied every 12 hours is the most appropriate dose to use for second trimester termination
ที่มา
Journal of Obstetrics Gynaecology Research ปี 2544, June ปีที่: 27 ฉบับที่ 3 หน้า 125-128
คำสำคัญ
Misoprostol, Abortion, Second trimester pregnancy