A randomized controlled trial comparing ceftriaxone with cefazolin for antibiotic prophylaxis in abdominal hysterectomy
ณัฐชา พูลเจริญ, Sumanee Nilgate, Orapin Rattanapuntamanee, Sompop Limpongsanurak, สุรสิทธิ์ ชัยทองวงศ์วัฒนา*
Department of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
บทคัดย่อ
OBJECTIVE: To compare the effectiveness of ceftriaxone versus cefazolin for the prevention of febrile morbidity and postoperative infections among patients after abdominal hysterectomy.
METHODS: In a double-blind, randomized, controlled trial in Bangkok, Thailand, 320 patients undergoing abdominal hysterectomy between July 2008 and July 2009 were randomly assigned to receive 1g of either ceftriaxone or cefazolin intravenously in a single dose before surgery. The participants were evaluated for postoperative fever and infection for up to 4 weeks. χ(2) or Fisher exact tests were used for statistical analysis.
RESULTS: There was no significant difference between the ceftriaxone and cefazolin groups in incidence of febrile morbidity (9.4% versus 11.2%), wound infection (3.8% versus 1.9%), vaginal cuff infection (3.8% versus 1.9%), or urinary tract infection (1.9% versus 1.9%).
CONCLUSION: There was no difference between the use of single-dose preoperative ceftriaxone and cefazolin in preventing infectious morbidity among patients undergoing hysterectomy.
 
ที่มา
International Journal of Gynecology & Obstetrics ปี 2555, October ปีที่: 119 ฉบับที่ 1 หน้า 11-13
คำสำคัญ
Randomized controlled trial, Abdominal hysterectomy, Antibiotic prophylaxis