General Anesthesia with Sevoflurane After the Main Agent Halothane
Chumnanvej S, Vongvises P*
Department of Anesthesiology, Pramongkotklao Hospital, Bangkok 10400
Sevoflurane is a very low blood/gas partition coefficient (0.6-0.7) agent which allows it to provide easy adjustment of anesthesia levels during maintainance, and rapid offset of anesthesia at the end of the procedure but its cost is more expensive. Halothane is an agent with blood/gas partition coefficient (2.3) which allows the slow recovery from anesthesia but its cost is cheaper. The study was used alternative technique that use sevolurane after halathone. Whit the approval of the Ethic Committee and the patient inform consent, 24 ASA physical status I-II patients, aged 15-65 years old, scheduled for elective surgery more than 2 hours, were randomized in order to received either sevoflurane (n=12) or sevoflurane after halothane (n=12) as the main volatile anesthetic. At the moment of the peritonium suture, sevoflurane was given in the group who randomized to received the sevoflurane after halothane. At the moment of the last skin suture, the inhalation agents were discontinued and neuromuscular block was reversed. The recovery time from the end of anesthesia to the eyes opening and anesthetic complications were recorded. The cost of anesthetic agents were calculated. Results : The result of this study demonstrated that there was no significant difference in recovery time between two groups. Time to eye opening in sevoflurane alone is 12.91 ± 3.87 minutes and in sevolflurane after halothane is 10.5 ± 3.8 minutes. The cost of anesthesia in sevoflurane alone (945.76 ± 24.15 bahts) is more expensive than is sevoflurane after halothane (229.16 ±12.24 bahts). Conclusion : Technique which using sevoflurane after halothane anesthesia is save, no severe complications and suitable for long duration anesthesia. 
วิสัญญีสาร ปี 2545, July-September ปีที่: 28 ฉบับที่ 3 หน้า
General anesthesia, Recovery time