Comparison of desogestrel/ethinyl estradiol plus spironolactone versus cyproterone acetate/ethinyl estradiol in the treatment of polycystic ovary syndrome: A randomized controlled trial
Supatra Leelaphiwat, Theerayut Jongwutiwes, ศรีเธียร เลิศวิกูล*, Chotika Tabcharoen, มัธชุพร สุขประเสริฐ, ศศิวิมล รัตนศิริ, เสวก วีระเกียรติ
Department of Obstetrics and Gynecology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, 270 Rama 6 Road, Ratchatawee, Bangkok 10400, Thailand. Email: srithean.ler@mahidol.ac.th
บทคัดย่อ
Aim: To compare the effects of ethinyl estradiol (EE) 30 mcg/desogestrel 150 mcg plus spironolactone 25 mg/day (group A) versus EE 35 mcg/cyproterone acetate 2 mg (group B) on hyperandrogenism and metabolism in PCOS.
Methods: This was a randomized clinical study. Eighteen women in groups A and B received medications for three cycles. Acne score, androgens and metabolic parameters were assessed before and after treatment.
Results: One and two women in groups A and B, respectively, were excluded from the study. Both groups had significantly decreased acne score and free androgen index, and increased sex hormone-binding globulin levels. Cholesterol and high-density lipoprotein were significantly increased in group B, and androstenedione was significantly decreased in group A. The regular withdrawal bleeding was obtained in both groups.
Conclusion: Both regimens had quite similar efficacy on hyperandrogenism after three cycles of therapy and without any changes in metabolic parameters.
 
ที่มา
Journal of Obstetrics and Gynaecology Research ปี 2558, March ปีที่: 41 ฉบับที่ 3 หน้า 402-410
คำสำคัญ
Polycystic ovary syndrome, combined oral contraceptive pills, cyproterone acetate, desogestrel, spironolactone