Efficacy of tip cryotherapy in the treatment of idiopathic guttate hypomelanosis (IGH): a randomized, controlled, evaluator-blinded study
Kulwadee Laosakul, Premjit Juntongjin*
Division of Dermatology, Chulaborn International College of Medicine, Thammasat University, Pathum Thani, Thailand; E-mail:premjitvp@yahoo.com
Background: Idiopathic guttate hypomelanosis (IGH) is a common hypopigmentation affecting a large amount of older population. However, there is no standard treatment. Cryotherapy has been reported as an alternative therapy for years; nevertheless, there is no randomized controlled study to determine its efficacy.
Objectives: To evaluate the efficacy and side effects of tip cryotherapy in IGH treatment.
Material and methods: Total 101 lesions were included. Forty-three lesions were treated with cryotherapy and 58 lesions were assigned as control. A single session of tip cryotherapy was delivered and remained for 5 s. Colorimeter was used to measure lesional luminosity at baseline and then monthly until 4 months. Digital photographs were evaluated by two blinded dermatologists. In addition, patients’ assessments and side effects were assessed.
Results: Mean luminosity scale gradually decreased from baseline. Also, the score of the treated lesions has been significantly lower than that of the control lesions since week 8 (p = .005). At the fourth month, dermatologists’ assessment revealed that 82.3% of the treated lesions comparing to only 2% of the control showed more than 75% improvement (p < .001). Burning sensation was the most common side effect.
Conclusion: Tip cryotherapy appears to be an effective therapy with minimal adverse effect for IGH.
The Journal of Dermatological Treatment ปี 2560, May ปีที่: 28 ฉบับที่ 3 หน้า 271-275
idiopathic guttate hypomelanosis, tip cryotherapy, crytherapy, liquid nitrogen, cryosurgery, leukoderma, therapeutic wounding