Relationships Between Pharmaceutical Therapy–Related Quality of Lifeand Health Utility Scores in Thai Patients With Chronic Diseases
พรรณทิพา ศักดิ์ทอง
Department of Pharmacy Practice, Chulalongkorn University, Bangkok, Thailand; Email:
Objectives: The purpose of this study was to assess the relationships between pharmaceutical therapy–related quality of life (PTRQoL) and health utility (HU) scores since such data was not available.
Methods: The dataset of 1156 outpatients with chronic diseases from 3 public university hospitals in Bangkok, Thailand, were applied. The Patient-Reported Outcomes Measure of Pharmaceutical Therapy for Quality of Life (PROMPT-QoL) was utilized to assess PTRQoL. HU measures included EQ-5D-5L and EuroQoL-Visual Analog Scale (EQ-VAS). Multiple linear regressions using a stepwise approach were applied to evaluate the relationships between the PROMPT-QoL and the HU scores.
Results: The results found that the EQ-5D-5L was mostly correlated with the impacts of medicines and side-effects followed by the medicine effectiveness, psychologic impacts of medication use, and availability and accessibility domains of the PROMPT-QoL, respectively (actual R2about 18%). The EQ-VAS was mostly associated with the impacts of medicines and side-effects, followed by the medicine effectiveness and overall quality of life domains, respectively (actual R2about 14%).
Conclusions: The PROMPT-QoL had medium correlations with the EQ-5D-5L and EQ-VAS scores. Their relationships depended on HU approaches used. More research is needed to examine the relationships between the PROMPT-QoL or other PTRQoL instruments and other HU scores in other settings and populations.
Value in Health Regional Issues ปี 2563, May ปีที่: 21 ฉบับที่ หน้า 222-225
Quality of life, Thailand, Health utility, EQ-5D-5L, EQ-VAS, medicine/pharmaceutical/drug therapy